DIATHEVA - Biomanufacturing of innovative diagnostics and reagents

Recombinant Thymidine Phosphorylase

Description: Thymidine phosphorylase (TYMP) is an enzyme involved in pyrimidine metabolism; the enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.


Product type: Recombinant protein


Expression system: E. coli


Peptide: Recombinant full length protein E.coli thymidine phosphorylase aminoacidic sequence Accession number: NP_290996


DOWNLOAD PROTOCOL


 

Ask for the price

Info

Defects in TYMP are the cause of mitochondrial DNA depletion syndrome type 1 (MTDPS1) also known as myoneurogastrointestinal encephalomyopathy, a multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy. Thymidine phosphorylase (TYMP) is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TYMP is overexpressed in various tumors and plays an important role in angiogenesis, tumor growth, invasion and metastasis.

Tested by: SDS Page, Western Blotting, Enzymatic activity

Purity: >95% pure estimated by SDS-PAGE (EU Ph. 5.0 § 2.5.31)

Form: Liquid

Storage buffer: 20mM K2HPO4/NaH2PO4 pH 7.5; 140mM NaCl; 3mM MSH; 10% glycerol.

 

Company certified
ISO9001
Certified N.
IT05/0576
crm@diatheva.com
Phone (+39) 0721 830605
Fax (+39) 0721 837154
 
website netcompany
P.IVA.01403060427

By navigating this website you provide your agreement to the use of cookies, which we use to improve your navigation experience and for statistical analysis. Read our Cookie Policy to learn more

Your Shopping Cart

 x 
Cart empty