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Recombinant Thymidine Phosphorylase

Description: Thymidine phosphorylase (TYMP) is an enzyme involved in pyrimidine metabolism; the enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Product type: Recombinant protein

Expression system: E. coli

Peptide: Recombinant full length protein E.coli thymidine phosphorylase aminoacidic sequence Accession number: NP_290996



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Defects in TYMP are the cause of mitochondrial DNA depletion syndrome type 1 (MTDPS1) also known as myoneurogastrointestinal encephalomyopathy, a multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy. Thymidine phosphorylase (TYMP) is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TYMP is overexpressed in various tumors and plays an important role in angiogenesis, tumor growth, invasion and metastasis.

Tested by: SDS Page, Western Blotting, Enzymatic activity

Purity: >95% pure estimated by SDS-PAGE (EU Ph. 5.0 § 2.5.31)

Form: Liquid

Storage buffer: 20mM K2HPO4/NaH2PO4 pH 7.5; 140mM NaCl; 3mM MSH; 10% glycerol.


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