Recombinant Human FKBP12

Recombinant human FKBP12 with N-terminal His-tag, expressed in E. coli and purified through a Nichel-affinity chromatography followed by gel filtration.

SKU: REP0036 Categories: , , ,
Product type: Reagents for research
Reagent type: Recombinant protein
Size: 100 µg

Description

FKBP12 is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after organ transplant and patients suffering from autoimmune disorders.[3] Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds cyclophilin.[4] Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called calcineurin, thus blocking signal transduction in the T-lymphocyte transduction pathway.[5] This therapeutic role is not related to prolyl isomerase activity.

Additional information

Size 100 µg
Application Clinical diagnostics| Life Sciences
Product type Reagents for research
Reagent type Recombinant protein
Category Cyclophilins

Technical information

Accession number UniProtKB/Swiss-Prot: P62942.2
Organism Human
Size 100 µg
Expression system E.coli
Tag HIS tagged
Purity >99%
Form Liquid, 50mM Hepes pH 8.0, 150mM NaCl, 0,5mM EDTA, 1mM sodium azide
Tested application SDS-PAGE
Shipping/storage conditions Shipped at -20°C. The protein is stable for 12 months if stored at -80°C. Avoid repeated freeze/thaw cycles.
Usage For Laboratory Research Use Only

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