Recombinant (HIV-1) Tat Clade C produced in E.coli. The HIV-1 Tat protein Clade C is a molecule of 101 aminoacids encoded by two exons.
Recombinant TAT Clade C
HIV-1 lineages are divided in three main groups, M (for Major), O (for Outlier), and N (for New, or Non-M, Non-O). The vast majority of strains found worldwide belong to the group M. Group O seems to be endemic to and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. The group N is represented by a limited number of isolates from Cameroonian persons. The group M is further subdivided in 9 clades or subtypes (A to D, F to H, J and K).
HIV-1 regulatory tat protein plays an essential role in viral replication and infectivity. In addition, during acute infection tat is released in the extracellular environment by infected cells and is taken up by neighbouring cells where it transactivates viral replication and increases virus infectivity. The HIV-1 tat protein is a molecule of 101 aminoacids encoded by two exons.
|Application||Clinical diagnostics| Life Sciences|
|Product type||Reagents for research|
|Reagent type||Recombinant protein|
|Subcategory||TAT Protein (Transactivating regulatory protein)|
|Accession number||UniProt Q900K4|
|Organism||Characterization of the South African HIV type 1 subtype C complete 5' long terminal repeat, nef, and regulatory genes JOURNAL AIDS Res. Hum. Retroviruses 18 (2), 149-159 (2002)|
|Potency||Not biologically Active protein|
|Form||Lyophilized with 0.1% glycerol.|
|Tested application||WB, SDS-PAGE, Endotoxins, Up-take, Rescue assay|
|Solubility||The protein should be reconstituted in apirogenic sterile water or 1X PBS|
|Shipping/storage conditions||Shipped at RT. The lyophilized protein is stable for 24 months if stored at -20°C. The reconstituted solution has to be used immediately. Avoid freeze-thaw cycles.|
|Usage||For Laboratory Research Use Only|
|Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort||PUBMED ID: 27450538|