Rabbit Anti HIV-I Tat

The HIV-1 regulatory protein Tat is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. The rabbit polyclonal Anti HIV-1 Tat antibody is a useful tool for detecting Tat transactivating regulatory protein

SKU: ANT0001 Categories: , , ,
Product type: Reagents for research
Reagent type: Antibody
Size: 200 µL

Description

The HIV-1 regulatory protein Tat is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. This protein is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. The protein is well conserved among isolates and thus may be less susceptible to mutation leading to the production of escape virus variants. Tat is produced early after infection and it’s essential for virus replication and infectivity. Tat protein is also immunogenic and antibody against Tat have been correlated with delayed disease progression and may exert protective effects inhibiting HIV-1 replication. Moreover, Tat is efficiently taken up by monocyte-derived dentritic cells, promoting their maturation. Finally, murine vaccination wwith a biologically active Tat protein has been shown to be safe and immunogenic.

Additional information

Size 200 µL
Application Clinical diagnostics| Life Sciences
Product type Reagents for research
Reagent type Antibody
Category HIV
Subcategory Polyclonal Anti Tat antibody
Antibody type Primary antibody
Immunogen Recombinant purified Tat protein (HIV-1 Clade B) expressed in E.coli

Technical information

Size 200 µL
Purity Purified by Protein A affinity Chromatography
Form Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.
Usage For Laboratory Research Use Only
Source Rabbit
Specificity Tat protein Clade A and B, GST-Tat fusion protein, Tat-Cys22 mutated in the trans activation domain and various Tat peptides
React with Tat from HIV-1
Recommended dilutions Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.

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References

DNA Vectors Generating Engineered Exosomes Potential CTL Vaccine Candidates Against AIDS, Hepatitis B, and Tumors PUBMED ID: 30167966
Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4+ T lymphocytes and reactivation of the HIV-1 reservoir PUBMED ID: 28474225
The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes PUBMED ID: 28474333

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