Recombinant Human Progerin

Recombinant human Progerin is a 614 amino acids protein with a molecular weight of about 68 kDa and is produced in E.coli.

SKU: REP0051 Categories: , , ,
Product type: Reagents for research
Reagent type: Recombinant protein
Size: 50 µg

Description

Progerin is a 614 amino acids protein involved in Hutchinson-Gilford progeria syndrome. In most cases, Progerin is generated by a point mutation (C1824T) in the LMNA gene that codes for lamin A and C. This mutation activates a cryptic splice site and gives rise to a form oflamin A with a 50-amino acids internal deletion within the carboxyl-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of LMNA gene.

Additional information

Size 50 µg
Application Clinical diagnostics| Life Sciences
Product type Reagents for research
Reagent type Recombinant protein
Category Laminopathies

Technical information

Accession number GenBank AAR29466
Size 50 µg
Expression system E.coli
Tag His tagged
Purity >90%
Form Liquid in 20mM phosphate buffer pH 7.0, 0.5M NaCl, 1mM DTT, 1.5mM EDTA, 20%(v/v) glycerol.
Tested application SDS-PAGE, WB
Shipping/storage conditions Shipped at -20°C. The protein is stable for 12 months if stored at -80°C. Avoid freeze-thaw cycles.
Usage For Laboratory Research Use Only

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References

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