Recombinant human Progerin is a 614 amino acids protein with a molecular weight of about 68 kDa and is produced in E.coli.
Recombinant Human Progerin
Progerin is a 614 amino acids protein involved in Hutchinson-Gilford progeria syndrome. In most cases, Progerin is generated by a point mutation (C1824T) in the LMNA gene that codes for lamin A and C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acids internal deletion within the carboxyl-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of LMNA gene.
|Clinical diagnostics| Life Sciences
|Reagents for research
|Liquid in 20mM phosphate buffer pH 7.0, 0.5M NaCl, 1mM DTT, 1.5mM EDTA, 20%(v/v) glycerol.
|Shipped at -20°C. The protein is stable for 12 months if stored at -80°C. Avoid freeze-thaw cycles.
|For Laboratory Research Use Only