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Recombinant Nef Clade B

Description: HIV-1 Nef is a 27kDa protein abundantly produced shortly after virus infection. Nef is an essential factor for efficient viral replication and pathogenesis, it also facilitates virus replication and enhances virions infectivity. Nef exerts pleiotropic effects: down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK, protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Nef protein bypasses host T-cell signaling by inducing a trascriptional program nearly identical to that of anti-CD3 cell activation.

Product type: Recombinant protein

Peptide: Recombinant full length protein: HIV-1 Nef – Accession number:CAA41585

Expression system: E.coli

Tested by: SDS-PAGE, HPLC, endotoxin assay

Purity: >90% estimated by analysis of Comassie blue-stained SDS-PAGE and HPLC.


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Form: Lyophilized. The protein should be reconstituted in apirogenic sterile water or 1X PBS.

Storage buffer: Preservative 1% glycerol

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