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Recombinant Cyclophilin A

Description: Cyclophilin A (CypA, 18 kDa) is the first peptidyl-prolil cis-trans isomerase (PPIase) to be discovered; PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins.

Product type: Recombinant protein

Peptide: Full length protein: Human CYPA protein fused with His-tag (N-terminus) – Accession number: NM_021130.3

Expression system: E.coli

Tested by: Western Blotting, SDS Page.

Purity: >99% pure as estimated by SDS-PAGE (EU Ph. 5.0 § 2.5.31)


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Cyclophilins belong to the superfamily of immunophilins, highly conserved cytoplasmic proteins which share the PPI enzymatic activity and the ability to bind immunosuppressive drugs. CypA binds to and mediates the effect of Cyclosporin A; the CsA/CypA complex selectively binds and inactivates the serine/theronine phosphatase calcineurin leading to disruption of T-cells activating cascade. CsA binding occurs at the active site of the protein thus inhibiting its enzymatic activity. CypA has been demonstrated to be involved in several steps of viral infections such as those mediated by HIV, HBV and HCV.

Form: Liquid

Storage buffer: 20mM Tris pH 8.0, 20mM NaCl, 0.5mM DTT, 10%(v/v) glycerol.

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