Rabbit anti Fusobacterium Nucleatum

Fusobacterium nucleatum is a Gram-negative bacterium that is commonly found in the dental plaque of humans and is frequently associated with gum disease. The antibody against F. Nucleatum is an aid in the oral pathogens research and in the diagnostic test development.

SKU: ANT0084 Categories: , , ,
Product type: Reagents for research
Reagent type: Antibody
Size: 200 µL

Description

Fusobacterium nucleatum has been shown to play a central role in dental plaque formation and other diseases like gingivitis. This is due to its ability to adhere to a wide range of both Gram-positive and Gram-negative plaque microorganisms. F. nucleatum is very often associated with periodontitis, along with invasive human infections of the head and neck, chest, lung, liver and abdomen. Due to its adherence ability, it can be associated with viruses, which adhere to host tissue cells as an invasion and modulate the host’s immune response. The pathogenic potential of Fusobacterium nucleatum and its significance in the development of periodontal diseases, as well as in infections in other organs, have gained new interest for several reasons. First, this bacterium has a very high chance to be pathogenic because of its high frequency in periodontal lesions, its production of irritants that affect the tissue, its ability to co-aggregate and form mutual synergisms with other bacteria in mixed infections and its ability to form numerous aggregates with other suspected pathogens in periodontal disease. Secondly, F. nucleatum is very common in clinical infections of other body sites. In the last few years it is intensively investigated the role of Fusobacterium nucleatum in atherosclerosis development and in promoting or inflicting different cancers.

Additional information

Size 200 µL
Application Clinical diagnostics|Life Sciences
Product type Reagents for research
Reagent type Antibody
Category Oral pathogens
Subcategory Polyclonal anti F. Nucleatum
Antibody type Primary antibody
Immunogen F. Nucleatum ATCC 25586 inactivated cells

Technical information

Size 200 µL
Purity Purified by affinity Chromatography
Form Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.
Usage For Laboratory Research Use Only
Source Rabbit
Specificity Antibody specifically binds F. Nucleatum
React with Antibody binds Fusobacterium Nucleartum
Recommended dilutions Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.

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References

A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry PUBMED ID: 27032997
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