Rabbit anti Porphyromonas gingivalis

Porphyromonas gingivalis is an anaerobic, Gram-negative bacterium that can be found in individuals’ oral cavities This bacterium is the principal source of periodontal disease. It has been found that in addition to causing human infections, the antibody against P. gingivalis is an aid in the oral pathogens research and in the diagnostic test development.

SKU: ANT0085 Categories: , , ,
Product type: Reagents for research
Reagent type: Antibody
Size: 200 µL

Description

Porphyromonas gingivalis has been found that in addition to causing human infections, this bacterium also causes much of the antibiotic resistance problems found today. The way which it operates is unique, since it is a Gram-negative bacteria, it can attach to the subgingival coating of the tooth, and it will substitute the Gram-positive bacteria originally there, leading to an inflammation which will disengage the gums from the teeth. The bacterium P. gingivalis, in addition to others, causes gingivitis as well as periodontis. Gingivitis is “A disorder involving inflammation of the gums; may affect surrounding and supporting structures of the teeth.” Periodontis is “inflammatory reaction of the tissues surrounding a tooth (periodontium), usually resulting from the extension of gingival inflammation into the periodontium.” When a gathering of Gram-negative, anaerobic bacteria is observed on the gums, it develops a biofilm called plaque on the tooth. Here P. gingivalis expresses proteolytic enzymes which regulate the protein function in the body, affecting the link between the tooth and the bone, ultimately causing the separation of the two and the taking apart of the tooth from jaw. In the last few years it has also been intensively investigated the role of P. gingivalis in atherosclerosis development and in promoting or inflicting different cancers.

Additional information

Size 200 µL
Application Clinical diagnostics| Life Sciences
Product type Reagents for research
Reagent type Antibody
Category Oral pathogens
Subcategory Polyclonal anti P. gingivalis
Antibody type Primary antibody
Immunogen Porphyromonas gingivalis ATCC 33277

Technical information

Size 200 µL
Purity Purified by affinity Chromatography
Form Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.
Usage For Laboratory Research Use Only
Source Rabbit
Specificity Antibody specifically binds P. Gingivalis
React with Antibody binds Porphyromonas gingivalism
Recommended dilutions Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.

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References

A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry PUBMED ID: 27032997
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