Porphyromonas gingivalis is an anaerobic, Gram-negative bacterium that can be found in individuals’ oral cavities This bacterium is the principal source of periodontal disease. It has been found that in addition to causing human infections, the antibody against P. gingivalis is an aid in the oral pathogens research and in the diagnostic test development.
Rabbit anti Porphyromonas gingivalis
Porphyromonas gingivalis has been found that in addition to causing human infections, this bacterium also causes much of the antibiotic resistance problems found today. The way which it operates is unique, since it is a Gram-negative bacteria, it can attach to the subgingival coating of the tooth, and it will substitute the Gram-positive bacteria originally there, leading to an inflammation which will disengage the gums from the teeth. The bacterium P. gingivalis, in addition to others, causes gingivitis as well as periodontis. Gingivitis is “A disorder involving inflammation of the gums; may affect surrounding and supporting structures of the teeth.” Periodontis is “inflammatory reaction of the tissues surrounding a tooth (periodontium), usually resulting from the extension of gingival inflammation into the periodontium.” When a gathering of Gram-negative, anaerobic bacteria is observed on the gums, it develops a biofilm called plaque on the tooth. Here P. gingivalis expresses proteolytic enzymes which regulate the protein function in the body, affecting the link between the tooth and the bone, ultimately causing the separation of the two and the taking apart of the tooth from jaw. In the last few years it has also been intensively investigated the role of P. gingivalis in atherosclerosis development and in promoting or inflicting different cancers.
|Application||Clinical diagnostics| Life Sciences|
|Product type||Reagents for research|
|Subcategory||Polyclonal anti P. gingivalis|
|Antibody type||Primary antibody|
|Immunogen||Porphyromonas gingivalis ATCC 33277|
|Purity||Purified by affinity Chromatography|
|Form||Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.|
|Shipping/storage conditions||Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.|
|Usage||For Laboratory Research Use Only|
|Specificity||Antibody specifically binds P. Gingivalis|
|React with||Antibody binds Porphyromonas gingivalism|
|Recommended dilutions||Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.|
|A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry||PUBMED ID: 27032997|