Antigen 85B is the most abundant protein exposed by Mycobacterium tuberculosis. It is a potent immunoprotective antigen and a leading drug target. It is a mycolyl transferase in the myc pathway and catalyses – like Ag85A and Ag85C- the transfer of the fatty acid mycolate from one trehalose monomycolate to another, resulting in trehalose dimycolate and free trehalose and helping to build the cell wall.Polyclonal antiAg85B antibody is designed for the detection of LLO in in infected speciment as an useful tool in the research of mycobacterial tubercolosis infections
Rabbit Anti Mycobacterial tubercolosis Ag85B
Description
Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of most cases of tuberculosis (TB). First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell. Antigen 85B is the most abundant protein expressed by Mycobacterium tuberculosis (about one quarter). It is a myocolyc transferase in the myc pathway and catalyses – like Ag85A and Ag85C – the transfer of the fatty acid mycolate from one trehalose monomycolate to another, resulting in trehalose dimycolate and free trehalose and helping build the cell wall.
Additional information
| Size | 200 µL |
|---|---|
| Application | Clinical diagnostics|Life Sciences |
| Product type | Reagents for research |
| Reagent type | Antibody |
| Category | Mycobacterium paratubercolosis |
| Subcategory | Polyclonal anti Ag85B antibody |
| Antibody type | Primary antibody |
| Immunogen | Purified Ag85B recombinant protein expressed in E.coli |
Technical information
| Size | 200 µL |
|---|---|
| Purity | Purified by affinity Chromatography |
| Form | Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH. |
| Shipping/storage conditions | Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles. |
| Usage | For Laboratory Research Use Only |
| Source | Rabbit |
| Specificity | Ag85B from Mycobacterium tubercolosis infected specimens |
| React with | Ag85B from Mycobacterium tubercolosis |
| Recommended dilutions | Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values. |
Download
References
| Recombinant Bacillus subtilis spores for the delivery of Mycobacterium tuberculosis Ag85B-CFP10 secretory antigens | PUBMED ID: 27727129 |
