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SARS-CoV-2 Spike S1

The specific antibodies against different subunits of spike (S) protein of SARS-CoV-2 are excellent research tools for the research against coronavirus. Anti SARS CoV-2 Spike1 monoclonal antibody detects full-length Spike1 also in the glycosylated form. The antibody does not cross react with SARS CoV-2 Spike2 and SARS CoV-2 Spike1 RBD domain.

SKU: ANT0091 Categories: , , ,
Product type: Reagents for research
Reagent type: Antibody
Size: 100 μg

Description

Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. The specific antibodies against different subunits of spike (S) protein of SARS-CoV-2 are excellent research tools for the research against coronavirus

Additional information

Size 100 μg
Application Clinical diagnostics| Life Sciences
Product type Reagents for research
Reagent type Antibody
Category Covid-19
Subcategory Monoclonal antibody
Antibody type Primary antibody
Immunogen Conformational SARS-CoV-2 Spike 1

Technical information

Size 100 μg
Purity Mouse monoclonal immunoglobulins IgG2b subclass were purified by protein A affinity chromatography and stabilized with 0.05% of glycerol.
Form Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions Shipped at -20°C When stored at -20°C, the antibody is stable for 12 months.
Usage For Laboratory Research Use Only
Source mouse
Specificity Anti SARS CoV-2 Spike1 monoclonal antibody detects full-length Spike1 also in the glycosylated form. The antibody does not cross react with SARS CoV-2 Spike2 and SARS CoV-2 Spike1 RBD domain.
React with Conformational SARS-CoV-2 Spike 1
Additional notes When using any primary antibody or fluorescence-labelled secondary antibody for the first time, titrate out the antibody to determine which dilution allows the strongest specific signal with the lowest background for your sample.
Recommended dilutions Recommended starting dilutions can vary lot-to-lot.

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References

Clinical and Analytical Performance of an Automated Serological Test That Identifies S1/S2-Neutralizing IgG in COVID-19 Patients Semiquantitatively. doi: 10.1128/JCM.01224-20
Structures and distributions of SARS-CoV-2 spike proteins on intact virions. doi: 10.1038/s41586-020-2665-2
SARS-CoV-2-specific virulence factors in COVID-19. doi: 10.1002/jmv.26615

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