Description: The HIV-1 p17 is a structural protein critically involved in the life cycle of the retrovirus. It participates in the early stages of virus replication as well as in RNA targeting to the plasma membrane, incorporation of the envelope into virions and particle assembly. Besides its well established functions, p17 acts as a viral cytokine that works on preactivated - but not on resting - human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication after binding to a cellular receptor (p17R). Thus, p17 might play a key role in the complex network of host- and virus-derived stimulatory factors contributing to create a favourable environment for HIV-1 infection and replication.
Source: Mouse monoclonal IgG2b, 7
Recommended Dilutions: Western Blotting starting dilution 0.8>g/ml -3>g/ml, Immunofluorescence starting dilution 3>g/ml -63>g/ml
Note: When using any primary antibody or fluorescence-labelled secondary antibody for the first time, titrate out the antibody to determine the best dilution for the strongest specific signal with the least background. As control add into the single slip a secondary antibody only.
Purity: Monoclonal immunoglobulins affinity purified
Clonality: Monoclonal
Form: Ready to use prediluted in Na+ Citrate 0.1 M, 0.05 mM Tris and 0.05% v/v of glycerol. The antibody solution is at neutral pH.
Storage: Shipped at +4°C. When stored at +4°C the antibody is stable for 12 months. For extended storage, the solution may be frozen in working aliquots.