Description: HIV-I Tat protein is a regulatory protein of HIV virus, well conserved among different isolates. Tat is produced early after infection and it’s essential for virus replication and infectivity. Tat protein is also immunogenic and antibodies (Ab) against Tat have been found to correlate with delayed disease progression and may exert protective effects by inhibiting both HIV replication and the effects of extracellular Tat. Moreover, Tat is efficiently taken up by monocite-derived dendritic cells, promotes their maturation and antigen presenting since it enters the major histocompatibility complex class I pathway.Finally, murine vaccination with a biologically active Tat protein has been shown to be safe, immunogenic and elicits anti-Tat neutralizing Ab and CTL.
Source: Rabbit
Recommeded starting dilutions: Flow Cytometry 1:200
Purity: Purified by protein A affinity chromatography and conjugated by FITC.
Clonality: Polyclonal
Form: Ready to use pre-diluted in PBS and 0.05% v/v of glycerol.
Storage: Shipped at +4°C. When stored at +4°C the antibody is stable for 12 months. For extended storage, the solution may be frozen at –20°C in working aliquots.